Many drug substances show suboptimal physicochemical and mechanical properties leading poor manufacturability, stability and bioavailability. This program focuses on improving these properties through engineering materials structure (crystal engineering, cocrystals, amorphous solid dispersions..). It aims to train students in pharmaceutical forms and drug delivery.
Upon completion of this program students will be able to:
-Become familiar with the different solid forms (crystals, amorphous materials) in pharmaceutical materials and the processes for screening and production of them
-Recognize the role of excipients in creating and stabilizing pharmaceutical solid forms
-Evaluate process technology and processing conditions when formulating pharmaceutical solid forms by encapsulation
- Cours Magistraux : 45
- Travail Autonomie Libre, non programmé l'EDT : 21
- Evaluation des connaissances et capacités : DS, QCM, présentation orale : 3
effectifs minimal / maximal:4/7
UE de rattachement
Format des notesNumérique sur 20
Pour les élèves du diplômeAdvanced Pharmaceutical EngineeringLe rattrapage est autorisé (Max entre les deux notes écrêté à une note seuil)
Le coefficient de l'enseignement est : 3
Topics included are:
1. Solid form screening
Solid form screening, the activity of generating and analyzing different solid forms of an active pharmaceutical ingredient (API), is an essential part of drug development. The basic principles of solid form screening are introduced, including the methods used in experimental screening (generation, characterization and analysis of solid forms, data mining tools, and high-throughput screening technologies).
Liquid-solid equilibrium (solid-liquid equilibrium calculation; influence of particle size on solid-liquid equilibrium; experimental determination of solid-liquid equilibrium; definition of supersaturation).
Population balance (size distribution, population density definition; demonstration of population balance; application to crystallization (nucleation, growth and agglomeration)).
The objectives are to estimate the solubility of a solid in a solvent and to know how to use population balance in a simple case.
3. Crystal particle size reduction (micronisation-milling) and 4. Crystalline drug production - nanotechnologies
In recent years, nano-sized crystalline drugs have been accepted as a valuable drug delivery system for poorly water-soluble drugs. Top-down and bottom-up technologies are the two main approaches for generating nanosuspensions. These courses focuse on the preparation of nanosuspensions by the top-down technologies.
5. Amorphous state
This course focuses on fundamentals of amorphous state, techniques for its characterization and physical stabilization.
6. Particle design by encapsulation
Introduction to encapsulation and overview on encapsulation processes.