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Tronc Commun - MOD-M-ADPH-PhPcsDe-WD : Wet and Dry processes

Descriptif

Different humid and dry processes used in pharmaceutical industries are presented: Pharmaceutical powders compaction, Physics and mechanics of granular media for powder handling.

Objectifs pédagogiques

The objectives are given for each parts:

Pharmaceutical powders compaction

to understand the key concepts of compaction:

-Technology, state of the art in research / industry
-Challenges / advantages & limitation
-Main keys & good practices
-Role of material properties in the development
-Tableting process description
-Role of each ingredient in a given formulation regarding its behaviour

-Behaviour of primary particles and rolled granules regarding Tablet strength

 

Physics and mechanics of granular media for powder handling,

to understand the key concepts of powder handling

drying 

to understand the key concepts of drying

freeze drying 

to provide with up-to-date information about all aspects of the freeze-drying process, from formulation & process development to equipment description

milling

- to understand the key concepts of milling Context, concept and generalities
- to study the microscopic approach of milling
- to model milling with various approaches

10 heures en présentiel
réparties en:
  • Activité sportive : 10

Soit 20 heures de travail global estimé pour l’étudiant.

Diplôme(s) concerné(s)

UE de rattachement

Pour les élèves du diplômeAdvanced Pharmaceutical Engineering

-Thermodynamics / Phase equilibrium
-Mass and energy balances
-Hydraulics and dispersed systems
-Basical concepts of Chemistry and Physics
-Knowledge of heat and mass transfer phenomena.
-Numerical analysis (less important)

Format des notes

Numérique sur 20

Littérale/grade européen

Pour les élèves du diplômeAdvanced Pharmaceutical Engineering

Vos modalités d'acquisition :

Test, pactical work reprot, oral presentation with a poster

Le rattrapage est autorisé (Max entre les deux notes écrêté à une note seuil)

    Le coefficient de l'enseignement est : 4

    La note obtenue rentre dans le calcul de votre GPA.

    Programme détaillé

    Pharmaceutical powders compaction

    Compaction Process and material behaviour - lecture (3h)
    -Die-compaction process
    -Modelling compaction behavior of powders
    Dry granulation : roller compaction & Milling process - lecture (3h)
    -Dry granulation: background and theory
    -Roll press: design features / operating parameters
    -Milling process & granules
    -Roll compaction demonstration
    Case study distance learning (9h)
    -Bilayer tablets (report) - distance learning - 3h
    -Practical work to develop bilayer tablet using an instrumented press (1h30)

    Compaction of binary mixtures (report) - 3h
    Practical work: 1h30 to develop tablet of binary mixtures using an instrumented press

    Compaction behaviour of primary and roll compacted powders (granules) - 3h
    -Mechanism of rearrangement during densification
    -Relative volume variation according to the compressive pressure
    -Conclusion
    -Practical work : 1h30 to do compaction experiment with primary and granules using an instrumented press

    Milling
    Description of the used processes (mixing, filling & compaction) by mentioning the main expected problems regarding flowability, homogeneity & de-mixing, tablet strength, disintegration & dissolution
    Proposition of main processes to improve the formulation behaviour


    Physics and mechanics of granular media for powder handling
    -Basics of physics and mechanics of granular media for the understanding of the main issues in industrial powder handling and storage
    -Granular friction, Coulomb model, cohesion
    -Cohesive powders, Rumpf model, Statics of silos
    -Silo design: basics
    -Silo design: basics

    Practical work (3h): Yield locii obtained using a shear tester

    Drying

    - Differents steps of drying
    - The phenomena of heat transfer


    Freeze Drying

    -General introduction to freeze-drying technology

    -Formulation Characterization and Product Formulation Design

    -Cycle Development and Scale-Up aspect that includes Product Freezing, Primary and Secondary Drying

    -Product and Process Monitoring

    -PAT methods Conventional Cycle Development

    -Design (QbD) for freeze-drying

    -Product appearance issues

    -Container closure integrity

    -Modeling & simulation

    -Equipment description


    Milling

    -Context, concept and generalities
    -Microscopic approach, breakage mechanisms
    -Modelling: various approaches
    -How to model grinding phenomena
    -Modelling based on energy consumption
    -Modelling based on population balance
    The way to end-use properties (Ex: particles shape, case of amorphisation...)

    -Grinding in practice: some examples

    -Talc micronization (Dry way milling)
    -Talc, grinding processes, problem approach
    -Micronization continuous process (Markov chains modelling)
    -Batch micronization (Population Balance, morphology and breakage mechanisms)
    -Wet Milling
    -Vegetal material: use of grinding as a separation process
    -Mechanosynthesis

    Mots clés

    compaction, milieu granulaire, broyage

    Méthodes pédagogiques

    Cours, exercices et TP
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